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Immobilized Palladium Nanoparticles on Phosphanamine-grafted Cellulose for Arylation of Uracil

Author(s):

Qian Yang*, Na Ma , Yangqing He , Xiaojiao Yu and Binghua Yao   Pages 1 - 10 ( 10 )

Abstract:


Background: The synthesis of 5-arylation uracil nucleosides is an imperative challenge, especially for the method of Suzuki reaction using N-unprotected uracil as materials, which holds the potential to enhance the yield.

Objective: The objective of the study was to find a more efficient catalyst to increase the yield of aryluracils and aryluridines.

Methods: We first constructed the phosphanamine-grafted cellulose (PAGC) from cellulose material. Then, we prepared the nanocatalyst PAGC/Pd(0) through heating and reducing the mixture of PAGC and Pa(OAc)2.

Results: When using this nanocatalyst to catalyze the Suzuki reaction of 5-iodouracil or 5-iodouridine and aryl heterocyclic boronic acids, the arylation yields have been significantly improved.

Conclusion: This means that the resultant nanocatalyst exhibits a remarkable catalytic efficacy for Suzuki arylation of 5-iodouracil and 5-iodouridine.

Keywords:

Palladium nanocatalyst, phosphanamine, cellulose, suzuki arylation, iodouracil, iodouridine.

Affiliation:

School of Sciences, Xi`an University of Technology,Xi’an, 710054, School of Sciences, Xi`an University of Technology,Xi’an, 710054, School of Sciences, Xi`an University of Technology,Xi’an, 710054, School of Sciences, Xi`an University of Technology,Xi’an, 710054, School of Sciences, Xi`an University of Technology,Xi’an, 710054



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