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An Efficient One-pot Stereoselective Synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans

[ Vol. 8 , Issue. 3 ]


Chithaluri Sudhakar* and Pochamoni Ramudu   Pages 266 - 270 ( 5 )


An efficient stereoselective synthesis of 2,6-disubstituted-4-thiocyanatotetrahydropyrans has been developed through a one-pot three-component reaction of aldehydes, trimethyl allylsilane, and NH4SCN in the presence of BF3.Et2O at room temperature. The products are formed rapidly (10-30 min) in excellent yields (78-98%).


Aldehydes, allyl trimethylsilane, lewis acid, prins cyclization, thiocyanatotetrahydropyran, one-pot reaction.


Department of Chemistry, GITAM School of Science, GITAM Deemed to be University, Telangana-502 329, Department of Chemistry, PG center wanaparthy, Palamuru University, Telangana – 509001

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