Chithaluri Sudhakar* and Pochamoni Ramudu Pages 266 - 270 ( 5 )
An efficient stereoselective synthesis of 2,6-disubstituted-4-thiocyanatotetrahydropyrans has been developed through a one-pot three-component reaction of aldehydes, trimethyl allylsilane, and NH4SCN in the presence of BF3.Et2O at room temperature. The products are formed rapidly (10-30 min) in excellent yields (78-98%).
Aldehydes, allyl trimethylsilane, lewis acid, prins cyclization, thiocyanatotetrahydropyran, one-pot reaction.
Department of Chemistry, GITAM School of Science, GITAM Deemed to be University, Telangana-502 329, Department of Chemistry, PG center wanaparthy, Palamuru University, Telangana – 509001