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One Pot Multicomponent Biginelli Reaction Employing Ionic Liquids as an Organocatalyst

[ Vol. 7 , Issue. 2 ]

Author(s):

Tanveer M. Shaikh*, Sankaranarayanan Nagarajan and Elango Kandasamy*   Pages 96 - 107 ( 12 )

Abstract:


Introduction: The N-heterocyclic compounds have been extensively studied in pharmaceutical industries. Furthermore, syntheses of such compounds employing organo-catalyst have been associated with sustainable technology.

Methods: The synthesis of new, stable ionic liquids and their catalytic applications in one-pot multicomponent Biginelli reaction is presented. The method provides broad substrate scope, yielding the corresponding 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones, in good to excellent yields, respectively.

Results and Conclusion: The developed reactions are associated with certain advantages, short reaction time and sustainable conditions. The protocol has advantages eco-friendly procedure, recovery and reusability of catalyst, which showed consistent activity.

Keywords:

Biginelli reaction, multicomponent, Ionic liquid, organocatalyst, dihydropyrimidinones, dihydropyrimidinthiones.

Affiliation:

Department of Chemistry, CNCS, Mekelle University, Mek'ele, Department of Science and Humanities, PSN Engineering College, Mela-thediyoor, Tirunelveli, Dhanvanthri Lab, Department of Sciences, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham

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