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One Pot Multicomponent Biginelli Reaction Employing Ionic Liquids as an Organocatalyst

[ Vol. 7 , Issue. 2 ]


Tanveer M. Shaikh*, Sankaranarayanan Nagarajan and Elango Kandasamy*   Pages 96 - 107 ( 12 )


Introduction: The N-heterocyclic compounds have been extensively studied in pharmaceutical industries. Furthermore, syntheses of such compounds employing organo-catalyst have been associated with sustainable technology.

Methods: The synthesis of new, stable ionic liquids and their catalytic applications in one-pot multicomponent Biginelli reaction is presented. The method provides broad substrate scope, yielding the corresponding 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones, in good to excellent yields, respectively.

Results and Conclusion: The developed reactions are associated with certain advantages, short reaction time and sustainable conditions. The protocol has advantages eco-friendly procedure, recovery and reusability of catalyst, which showed consistent activity.


Biginelli reaction, multicomponent, Ionic liquid, organocatalyst, dihydropyrimidinones, dihydropyrimidinthiones.


Department of Chemistry, CNCS, Mekelle University, Mek'ele, Department of Science and Humanities, PSN Engineering College, Mela-thediyoor, Tirunelveli, Dhanvanthri Lab, Department of Sciences, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham

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