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Malic Acid as Bioorganocatalyst: Sustainable, One-pot and Multicomponent Synthesis of Benzopyrimido[4,5-b]quinoline in Biodegradable Glycerol

[ Vol. 5 , Issue. 3 ]

Author(s):

Akhilesh Kumar, Pragati Rai, Vijay B. Yadav, Hozeyfa Sagir and I. R. Siddiqui*   Pages 239 - 245 ( 7 )

Abstract:


Background: Herein we disclosed a clean and sustainable, one pot, multicomponent protocol for the synthesis of Benzopyrimido[4,5-b]quinoline in glycerol in the presence of malic acid.

Methods: The reported strategy eliminates the use of hazardous transition metal catalysts, acid, base and volatile organic solvents, which negatively affect the environment. In addition present methodology has advantages of mild reaction conditions, wide substrate scope, operational simplicity, easy workup, cost effectiveness and high yields of desired products.

Conclusion: We have presented an efficient malic acid promoted, environmentally benign synthetic route to highly functionalized benzo[f]pyrimido[4,5-b]quinoline derivatives.

Keywords:

5-b]quinolone, benzopyrimido, cost effectiveness, malic acid, multicomponent, yields.

Affiliation:

Laboratory of Green Synthesis, Department of Chemistry University of Allahabad, Allahabad-211002, Laboratory of Green Synthesis, Department of Chemistry University of Allahabad, Allahabad-211002, Laboratory of Green Synthesis, Department of Chemistry University of Allahabad, Allahabad-211002, Laboratory of Green Synthesis, Department of Chemistry University of Allahabad, Allahabad-211002, Laboratory of Green Synthesis, Department of Chemistry University of Allahabad, Allahabad-211002

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