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Sarcosine as a Novel and Recyclable Organocatalyst: A Greener Approach Towards the Synthesis of Multisubstituted Pyrazole Derivatives

[ Vol. 5 , Issue. 3 ]

Author(s):

Deepali Jaiswal, Jyoti Tiwari, Shailesh Singh, Amit Kumar Sharma, Jaya Singh and Jagdamba Singh*   Pages 229 - 238 ( 10 )

Abstract:


Background: A highly efficient eco-friendly route for the synthesis of pyrazole derivatives from readily available chalcones/1, 3-diketones and hydrazines in glycerol using sarcosine as a novel organopromoter has been developed. To the best of our knowledge this is the first report on the use of sarcosine as an organocatalyst in organic transformations.

Results and Methods: This method manifests several attributes of green chemistry like atomeconomy, reusability of catalyst, short reaction time and an eco-friendly medium.

Conclusion: The present protocol can serve as a valuable green alternative to the existing methods for the synthesis of targeted molecules.

Keywords:

Catalysis, glycerol, green synthesis, pyrazole, sarcosine.

Affiliation:

Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Department of Chemistry, LRPG College, Sahibabad, Ghaziabad-201005, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002

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