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Synthesis of Urea Derivatives using Carbon Dioxide as Carbonylation Reagent in Ionic Liquids

[ Vol. 4 , Issue. 2 ]

Author(s):

Xing He , Xiao-Ya Li , Yu Song, Shu-Mei Xia , Xian-Dong Lang and Liang-Nian He *   Pages 112 - 121 ( 10 )

Abstract:


Urea and its derivatives, which are usually generated through the carbonylation reaction between amines and carbonylation reagent, have been found widespread applications in agriculture and pharmaceuticals. Among the carbonylation reaction, it is the most appealing and promising strategy that employs CO2 as a green carbonylation reagent. However, CO2 inherent thermodynamic stability and kinetic inertness limit its application. Apart from being regarded as one of the green solvents, ionic liquid is also an efficient organocatalyst for CO2 capture or activation due to the interaction between CO2 with cation or anion of ionic liquid. In this mini-review, we have summarized representative synthetic methodologies of urea derivatives using carbon dioxide as a green carbonylation reagent and using ionic liquids as solvents and/or organocatalysts.

Keywords:

Activation, carbon dioxide, carbonylation, ionic liquid, organocatalyst, urea derivatives.

Affiliation:

State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin

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