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Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds

[ Vol. 3 , Issue. 2 ]

Author(s):

Avik Kumar Bagdi, Dhiman Kundu, Adinath Majee and Alakananda Hajra   Pages 169 - 175 ( 7 )

Abstract:


An efficient, simple and environmentally benign methodology has been developed for the synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives by a three-component condensation of β-keto esters, amines and α,β-unsaturated aldehydes under solvent-free conditions catalyzed by an aprotic imidazole-based zwitterionic salt. The key advantages of this protocol are metal-free reaction conditions, short reaction time, high yields, reusability of the catalyst, and easy work-up. A variety of dihydropyridine derivatives have been synthesized with high yields at room temperature and only water is formed as a green by-product.

Keywords:

Dihydropyridines, imidazolium zwitterion, multicomponent, organocatalysis, reusability, solvent-free.

Affiliation:

Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235



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