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DBU-Catalyzed One-Pot Multicomponent Reaction for the Synthesis of Spirocyclic Tetrahydrothiophene Derivatives

[ Vol. 3 , Issue. 2 ]


Jindian Duan, Jing Cheng and Pengfei Li   Pages 216 - 220 ( 5 )


A DBU-catalyzed one-pot multicomponent reaction involving indane-1,3-dione, aldehydes, and 1,4-dithiane-2,5-diol for the synthesis of spirocyclic tetrahydrothiophene derivatives has been developed. A series of spirocyclic tetrahydrothiophene derivatives were obtained in generally good to excellent yields with high diastereoselectivity via this synthetic strategy. Importantly, this methodology has several advantages, such as mild reaction conditions, broad scope of substrates, easy operations and so on.


Aldehydes, DBU, 1, 4-dithiane-2, 5-diol, indane-1, 3-dione, multi-component reaction, one-pot, organocatalysis, tetrahydrothiophene.


Department of Chemistry, South University of Science and Technology of China, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong, 518055

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