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L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes

[ Vol. 2 , Issue. 1 ]

Author(s):

K. Srinivas, Naresh Kumar Katari, P. Satya Karuna and M.S. Surendra Babu   Pages 44 - 50 ( 7 )

Abstract:


L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2- nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3- carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The isolation procedure is quiet easy and products recovered without further purification.

Keywords:

2-cyanomethyl benzimidazole, ethylcyanoacetate, indole-3-carboxaldehydes, knoevenagel reaction, L-arginine, Onitroaniline.

Affiliation:

Department of Chemistry, GITAM School of Technology, GITAM University, Hyderabad Technological Park campus, Rudraram, Medak (A.P.) - 502 329, India.

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